What's up in

CRISPR

Q&A

Doudna’s Confidence in CRISPR’s Research Potential Burns Bright

February 27, 2019

Jennifer Doudna, one of CRISPR’s primary innovators, stays optimistic about how the gene-editing tool will continue to empower basic biological understanding.

Abstractions blog

Gene Drives Work in Mice (if They’re Female)

January 23, 2019

Biologists have demonstrated for the first time that a controversial genetic engineering technology works, with caveats, in mammals.

Art for "In the Nucleus, Genes’ Activity Might Depend on Their Position"
cell biology

In the Nucleus, Genes’ Activity Might Depend on Their Location

November 6, 2018

Using a new CRISPR-based technique, researchers are examining how the position of DNA within the nucleus affects gene expression and cell function.

Photo of Emmanuelle Charpentier, Virginijus Šikšnys, Jennifer Doudna
Abstractions blog

CRISPR Gene-Editing Pioneers Win Kavli Prize for Nanoscience

May 31, 2018

The inventors of a “Swiss army knife” for genome editing received prestigious honors, as did pioneering scientists in astrophysics and neuroscience.

In the ongoing controversy over whether and how to use a powerful new genome editing technology in the wild to achieve conservation and public health goals, two new papers urge caution.
Abstractions blog

New Model Warns About CRISPR Gene Drives in the Wild

November 16, 2017

Two new papers urge caution in using powerful genome-editing technology against invasive species: Models show that aggressive gene drives can’t be contained in the wild.

evolution

Genetic Engineering to Clash With Evolution

September 8, 2016

Gene drives promise to spread a trait across an entire population. But evolutionary forces are going to alter even the best-engineered plans.

Biology

Breakthrough DNA Editor Born of Bacteria

February 6, 2015

Interest in a powerful DNA editing tool called CRISPR has revealed that bacteria are far more sophisticated than anyone imagined.