Ethics

With embryolike constructs built entirely from stem cells, researchers can revolutionize our understanding of development. But how close to an embryo is too close?

With stem cell technology and lab-grown brain organoids, Sergiu Paşca seeks the causes of autism and other neuropsychiatric conditions.

Letting human brain organoids grow in animal brains could be an ethical new option for experimental studies of neurological disorders.

Collaborations in progress between ethicists and biologists seek to head off challenges raised by lab-grown “organoids” as they become increasingly similar to human brain tissue.

Modeling suggests that many embryonic cells commit to a developmental fate when they become too small to divide unevenly anymore.

Jennifer Doudna, one of CRISPR’s primary innovators, stays optimistic about how the gene-editing tool will continue to empower basic biological understanding.

Mechanical tension between tethered cells cues developing tissues to fold. Researchers can now program synthetic tissue to make coils, cubes and rippling plates.

"Organoid" brain tissue models grown in a lab for two years can help scientists study a critical period of development just before and after birth.

To create a good living replica of the human brain, your best hope may be to let “organoid” components assemble it for you.