gene regulation

The molecular signaling systems of complex cells are nothing like simple electronic circuits. The logic governing their operation is riotously complex — but it has advantages.

New work shows that neurons and other brain cells use DNA double-strand breaks, often associated with cancer, neurodegeneration and aging, to quickly express genes related to learning and memory.

New work shows that histones, long treated as boring spools for DNA, sit at the center of the origin story of eukaryotes and continue to play important roles in evolution and disease.

The bizarre genome of the world’s most mysterious flowering plants shows how far parasites will go in stealing, deleting and duplicating DNA.

Inside cells, droplets of biomolecules called condensates merge, divide and dissolve. Their dance may regulate vital processes.

Theories about how animals became multicellular are shifting as researchers find greater complexity in our single-celled ancestors.

During development, cells seem to decode their fate through optimal information processing, which could hint at a more general principle of life.

For the first time, researchers have traced the genetic programs that guide the development of each cell in early embryos. Surprisingly, even cells that start out different can end up the same.

The computer scientist Barbara Engelhardt develops machine-learning models and methods to scour human genomes for the elusive causes and mechanisms of disease.