Gene regulation

C.H. Waddington’s powerful image of embryonic stem cells specializing on a rolling landscape has captivated biologists since the 1950s. Experimental data is finally confirming, and complicating, his visionary ideas.

The biologist’s bold “energetic view of life” looks to the body’s strangest organelles as the link between cells, health, and mind and the foundation of our experience of being alive.

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

Research into how a father’s choices — such as diet, exercise, stress, nicotine use — may transfer traits to his children has become impossible to ignore.

New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

Highly repetitive regions of junk DNA may be the key to a newly discovered mechanism for gene regulation.

Patterns that guide the development of feathers and other features can be set by mechanical forces in the embryo, not just by gradients of chemicals.

Synthetic biology experiments suggest a “MultiFate” model for how genetically identical cells become the many different types found in complex organisms like us.